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目的 :探讨术中超声引导下12 5I放射性粒子永久性植入治疗晚期胰腺癌的临床意义。方法 :回顾性分析 2 0 0 2年 5月至 2 0 0 2年 12月接受术中12 5I粒子植入治疗的 8例资料晚期胰腺癌。结果 :8例中植入粒子 19～ 38粒 ,平均 2 2 .8粒 ,周缘匹配剂量 (MPD) 6 5Gy。手术后 ,病人恢复良好 ,术后复查血常规未发现有骨髓抑制现象。手术前顽固性腹痛消失 (2 / 2 )。得到CT复查的 4例显示 ,肿瘤完全消失 2例 ,肿瘤明显缩小和略有缩小各 1例。全组无胰漏、胰腺炎并发症。结论 :放射性粒子12 5I植入对失去手术切除机会的胰腺癌局部控制效果满意 ,可有效缓解疼痛 ,是一种安全的治疗手段。
Objective: To investigate the clinical significance of intraoperative ultrasound-guided permanent 125 I radioactive seed implantation in the treatment of advanced pancreatic cancer. Methods: Eight cases of advanced pancreatic cancer who underwent intraoperative 125I seeds implantation from May 2002 to December 2002 were retrospectively analyzed. Results: In the 8 cases, 19 to 38 particles were implanted, with an average of 22.8 particles. The peripheral matching dose (MPD) was 65 Gy. After the operation, the patient recovered well. No postoperative bone marrow suppression was found in the blood routine after the operation. Stubborn abdominal pain disappeared before surgery (2/2). 4 cases of CT review showed that the tumor completely disappeared in 2 cases, the tumor was significantly reduced and slightly reduced in 1 case. The whole group without pancreatic leakage, pancreatitis complications. CONCLUSION: 125I radioactive particles implantation is a safe treatment for local pancreatic cancer patients who have lost the chances of surgical resection.