论文部分内容阅读
已知P物质(SP)为十一肽,对中枢神经系统有明显作用。某些具有较短氨基酸链的SP合成类似物对中枢神经系统也有作用。本文比较了SP及其两个六肽类似物N-2(SP_(6-11),H-甘-苯丙-苯丙-甘-亮-蛋-NH_2)和Z-1[(PGlu~6)SP_(6-11),焦谷-苯丙-苯丙-甘-亮-蛋-NH_2]的镇痛作用、对行为的影响以及与脑阿片受体结合的亲和性。以小鼠热板法测试SP的镇痛作用,发现SP腹腔注射(90和180nM/kg)能显著延长小鼠的舐足反应时间,这种作用的维持时间较长,腹腔注射后60分钟作用达到高峰,大剂量(180nM/kg)SP的作用较小剂量(90
It is known that substance P (SP) is an undecapeptide that has a significant effect on the central nervous system. Certain SP synthetic analogs with shorter amino acid chains also have effects on the central nervous system. In this paper, the effects of SP and its two hexapeptide analogues N-2 (SP_ (6-11), H-glycerophthalmic-phenylpropanophenanthropion-glutamine- SP_ (6-11), pyroglutamic acid-phenylpropyl-phenylpropyl-Gangen-egg-NH2], its effect on behavior and its affinity with brain opioid receptor. The analgesic effect of SP was tested by the hot plate method in mice. It was found that intraperitoneal injection of SP at 90 and 180 nM / kg significantly prolonged the response time of mice. This effect was sustained for a long time. After 60 minutes of intraperitoneal injection At the peak, the effect of high dose (180 nM / kg) SP was smaller (90%)