目的:观察调Q开关紫翠宝石激光治疗脂溢性角化病的临床疗效及评价其治疗前后的生活质量之变化。方法:利用调Q开关紫翠宝石激光治疗81例脂溢性角化病患者,根据皮损部位、性质选用不同的能量治疗且治疗前后通过问卷调查的形式了解患者术前的一般状况及治疗前后其生活质量的改变情况。结果:治疗1,2,3次的痊愈率分别为47.83%,85.71%,100%,而有效率分别为94.20%,100%,100%,显示治疗次数愈多,效果愈好。患者满意度为96.30%,医生满意度为92.60%;术前与术后DLQI总分P值<0.01,有显著统计学意义,提示治疗后总体生活质量获得提升。结论:调Q开关紫翠宝石激光治疗脂溢性角化病安全、有效,且可提升患者生活质量,值得推广。 Objective: To observe the clinical effect of Q-switched alexandrite laser on seborrheic keratosis and evaluate its changes before and after treatment. Methods: Eighty-one cases of seborrheic keratosis patients were treated by Q-switched alexandrite laser. According to the different parts of the lesions and the nature of the lesion, different energy treatments were used. Before and after treatment, the patients’ preoperative and postoperative symptoms were studied by questionnaire. The quality of life changes. Results: The cure rates of treatment 1, 2 and 3 times were 47.83%, 85.71% and 100% respectively, while the effective rates were 94.20%, 100% and 100% respectively. The satisfaction rate of patients was 96.30% and the satisfaction rate of doctors was 92.60%. The total score of DLQI before and after operation was less than 0.01, with significant statistical significance, suggesting that the overall quality of life improved after treatment. Conclusion: Q-switched alexandrite laser treatment of seborrheic keratosis is safe and effective, and can improve the quality of life of patients, it is worth promoting.