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目的:探讨超声下椎旁神经阻滞联合全身麻醉对开胸手术患者应用效果评价及对围术期应激的影响。方法:选取2016年1月至2018年1月期间70例在本院择期行开胸手术患者作为对象，采用随机分组表法把本次纳入研究患者分为对照组和观察组，对照组予以全身麻醉，观察组予以胸椎旁神经阻滞联合全身麻醉。比较两组患者麻醉期间血流动力学变化、麻醉效果、麻醉恢复情况，麻醉期间应激反应及不良反应发生情况。结果:两组患者在诱导1 min、插管1 min、拔管后1 min HR、平均动脉压(MAP)、血氧饱和度(SaOn 2)比较差异均无统计学意义(n P>0.05)。观察组患者的麻醉效果优于对照组(n P0.05). The anesthetic effect of the patients in the observation group was better than that of the control group (n P<0.05). The 2 h, 6 h, 12 h visual analogue score (VAS) score of patients in the observation group were lower than the control group (n P<0.05) . The levels of epinephrine and norepinephrine in the two groups were lower than that before anesthesia, and the levels of dopamine were higher than that before anesthesia (n P<0.05); 1 d after operation, the levels of adrenaline in the control group, blood glucose, dopamine and noradrenaline in the two groups were higher than those before anesthesia (n P<0.05); the blood glucose, epinephrine, dopamine, norepinephrine in the observation group after 1d were lower than that in the control group (n P0.05).n Conclusions:Ultrasound paravertebral block combined with general anesthesia can improve the anesthesia effect, and has better analgesic effect, less postoperative stress response, and high safety.