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背景:胆汁酸在肝内合成和分泌,因此可以作为反映肝细胞损害的指标之一。目的:探讨肝硬化患者血清总胆汁酸（TBA）测定的临床意义。方法:收集42例肝硬化患者的肝功能资料,比较TBA与其他常规肝功能指标的敏感性差异。结果:肝硬化组的TBA显著高于健康对照组（P<0.01）,其水平为健康对照组的6.9倍,异常率为74％,显著高于丙氨酸转氨酶（ALT）、r-谷氨酰转移酶（r-GT）和碱性磷酸酶（ALP）（P<0.01）。肝硬化失代偿期患者的TBA水平显著高于代偿期患者（P<0.01）。结论:TBA是反映肝硬化患者肝细胞损害的敏感指标之一。
Background: Bile acids are synthesized and secreted in the liver and therefore can be used as an indicator of liver cell damage. Objective: To investigate the clinical significance of serum total bile acid (TBA) in patients with cirrhosis. Methods: The data of liver function in 42 patients with cirrhosis were collected. The sensitivity of TBA to other conventional liver function indexes was compared. Results: TBA in cirrhosis group was significantly higher than that in healthy control group (P <0.01). The level of TBA in cirrhosis group was 6.9 times higher than that in healthy control group (74%), which was significantly higher than that of alanine aminotransferase (ALT) Acyltransferase (r-GT) and alkaline phosphatase (ALP) (P <0.01). Patients with cirrhosis decompensated significantly higher TBA than compensated patients (P <0.01). Conclusion: TBA is one of the sensitive indicators of liver cell damage in patients with cirrhosis.