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目的：分析持续性高容量血液滤过在脓毒症合并多器官功能障碍综合征治疗中的应用价值。方法选择2012年1月至2015年6月遵义医学院第五附属（珠海）医院 ICU 病房收治的106例脓毒症合并多器官功能障碍综合征患者，随机分为对照组和观察组，每组53例。对照组行常规容量血液滤过，观察组行持续性高容量血液滤过，对比分析两组患者的治疗效果。结果两组患者死亡率差异无统计学意义（P ＞0．05）。治疗后，两组患者生命体征均较治疗前改善，观察组 APACHEⅡ评分及 MODS 评分优于对照组，差异有统计学意义（P ＜0．05）。治疗后，两组患者血流动力学指标均较治疗前改善（P ＜0．05），观察组各项指标均优于对照组（P ＜0．05）。结论采用持续性高容量血液滤过治疗脓毒症合并多器官功能障碍综合征效果较好，能有效改善患者血流动力学，稳定生命体征，值得推广应用。“,”Objective To analyze the efficacies of continuous high -volume hemofiltration in the treatment of severe sepsis pa-tients with multiple organ dysfunction syndrome.Methods 106 severe species patients with multiple organ dysfunction syndrome, who were treated from January of 2012 to June of 2015,were randomly divided into control group and treatment group,53 cases in each group.Patients of the control group were given conventional volume hemofiltration,and patients of treatment group were given continuous high -volume hemofiltration.Therapeutic effects of the two groups were observed.Results There was no difference in mortality rate between two groups(P >0.05).After treatment,vital signs in two groups were improved,and APACHEⅡscore and MODS score in observation group were lower than control group(P <0.05).hemodynamic indicators were improved in both two groups before treatment(P <0.05),and the indicators were better than control group(P <0.05).Conclusion The treatment of continuous high volume hemofiltration in severe species patients with multiple organ dysfunction syndrome is more significant.It can effectively improve the patient’s hemodynamics,stable vital signs,and deserves the clinical expansion.