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目的:了解江西地区药品不良反应(ADR)发生的特点及引发ADR的相关因素,促进临床合理用药。方法:对江西地区2008年上报国家ADR监测中心的10033例ADR报告进行分类统计和分析。结果:由抗微生物药引发的ADR所占比例最高(53.76%),其次是中药制剂(16.68%);静脉滴注是最易引发ADR的给药途径(65.45%);严重ADR报告225例(2.24%),新的ADR报告412例(4.11%);严重ADR以全身性损害最为常见(99例);在225例严重ADR中,有后遗症、死亡各12例。结论:应进一步加强ADR的监测、通报和宣传工作。
Objective: To understand the characteristics of adverse drug reaction (ADR) in Jiangxi and the related factors that lead to ADR, and to promote the rational use of clinical medicine. Methods: A total of 10033 cases of ADR reported to the National ADR Monitoring Center in Jiangxi Province in 2008 were classified and analyzed. Results: The proportion of ADR caused by antimicrobials was the highest (53.76%), followed by that of traditional Chinese medicine (16.68%). The best route of ADR administration was intravenous drip (65.45%), and severe ADR was 225 2.24%), and 412 new cases (4.11%) were reported by ADR. The most common systemic injury was severe ADR (99 cases). There were sequelae and 12 deaths in 225 severe ADR cases. Conclusion: ADR monitoring, notification and advocacy should be further strengthened.