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目的:研究以硝酸咪康唑、地塞米松、丹皮酚为主药的咪松酚乳凝胶处方及其制备工艺。方法:通过油相(蓖麻油)量、水相(水∶甘油)量、乳化剂(聚山梨酯-80)量等为影响因素,以综合质量评定为评价指标,采用正交设计试验,优选咪松酚乳凝胶处方及其制备工艺。结果:优选工艺为油相(蓖麻油)为5mL,水相(水∶甘油)为32.5mL∶8mL,乳化剂(聚山梨酯-80)为1mL。结论:筛选的工艺制备出的凝胶质量稳定,操作简单。
OBJECTIVE: To study the formulation and preparation of miconophenol emulsion gel with miconazole nitrate, dexamethasone and paeonol as the main drugs. Methods: The effects of factors such as the amount of oil phase (castor oil), water phase (water: glycerol), emulsifier (polysorbate-80) and so on were evaluated. Miconic Emulsion Gel Formulation and Its Preparation Process. Results: The preferred process was 5mL oil phase (castor oil), 32.5mL: 8mL water phase (water: glycerol) and 1mL emulsifier (polysorbate-80). Conclusion: The gel prepared by screening process has stable quality and easy operation.