实验观察了怀牛膝总皂甙(ABS)对大、小白鼠的抗生育作用。结果显示,小鼠妊娠的第1～10天,灌胃给ABS具有显著的抗生育作用,此作用呈剂量(125～1000mg/kg)依赖性关系,其ED_(50)为218±48mg/kg)。小鼠妊娠的第1～5天,ABS500mg/kg灌胃给药具有明显的抗着床作用。但对大白鼠,ABS250～500mg/kg灌胃给药无抗生育作用;2g/kg灌胃时也无堕胎作用。 Experiments were conducted to observe the anti-fertility effects of Achyranthes bidentata saponins (ABS) on rats and mice. The results showed that on the 1st to 10th day of pregnancy, the mice fed with ABS had significant antifertility effects. The effect was dose-dependent (125-1000mg/kg). The ED 50 was 218±48mg/kg. ). On the 1st to the 5th day of pregnancy, ABS 500mg/kg administered intragastrically had a significant anti-implantation effect. However, in mice, ABS250 ~ 500mg/kg gavage administration did not have antifertility effects; 2g/kg gavage no abortion.