从鲜人参中提取分离出天然皂苷 ,模拟红参加工工艺过程 ,探讨红参加工中天然皂苷成分转化过程 ,以揭示出皂苷成分转化机理。方法 :将红参粉以甲醇提取 ,乙醚脱脂 ,正丁醇萃取 ;水层通过大孔树脂 (D10 1型 )吸附 ,水洗除去水溶性杂质和糖分。再经过硅胶柱层析和阳离子交换树脂柱层析 ,获得丙二酸单酰基人参皂苷。模拟红参加工工艺过程得转化物 ,对该转化物进行分离鉴定 ,诸如化学试验、IR、FD MS等仪器分析。结果表明 :从鲜人参中分离出丙二酸单酰基人参皂苷 Rb1和 Rb2 等皂苷 ,通过模拟红参加工试验发现在 75℃烘干过程 ,丙二酸单酰基人参皂苷 Rb2 转化为乙酰基人参皂苷 Rb2 ,即人参皂苷Rs1。结论 :人参皂苷Rs1是红参加工烘干阶段产生的 ,对其分解产物的分析有二氧化碳放出 ,说明该反应是丙二酸单酰基人参皂苷上的丙二元酸遇热发生脱羧降解反应所致 Natural saponins were extracted and separated from fresh ginseng to simulate the process of red participation in the process, and the conversion process of the natural saponins in the red participated in the process was explored to reveal the transformation mechanism of saponins. Methods: The red ginseng powder was extracted with methanol, and the ether was defatted and extracted with n-butanol. The water layer was adsorbed by macroporous resin (D10 type 1) and washed with water to remove water-soluble impurities and sugar. After silica gel column chromatography and cation exchange resin column chromatography, malonyl monoacyl ginsenosides were obtained. Simulated red to participate in the process of transformation obtained, the transformation of the identification and identification, such as chemical testing, IR, FD MS and other instrumental analysis. The results showed that the saponins such as malonylmononosyl ginsenosides Rb1 and Rb2 were isolated from fresh ginseng. Through the simulation of red participation in the experiment, it was found that during the drying process at 75°C, malonylmonosylenoside Rb2 was converted into acetyl ginsenosides. Rb2, namely ginsenoside Rs1. Conclusion : Ginsenoside Rs1 is produced during the drying stage of red process, and its decomposition product is analyzed by the emission of carbon dioxide, indicating that this reaction is caused by the decarboxylation and degradation reaction of malonyl diacids on malonylmonoacyl ginsenoside in the presence of heat.