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原发性肾上腺皮质功能减退 (Addison)症患者 ,其脱氢表雄酮 (DHEA)与雄激素水平降低。Addison患者即使应用糖皮质激素和盐皮质激素替代治疗有效 ,也会出现体力与精神疲劳 ,对应激的耐受力下降。在绝经前或绝经后女性Addison患者 ,其骨矿物质密度较同
Patients with primary adrenocortical hypofunction have decreased levels of DHEA and androgen. Addison’s patients experience physical and mental fatigue and reduced stress tolerance even though glucocorticoid and mineralocorticoid replacement therapy are effective. In premenopausal or postmenopausal women with Addison, their bone mineral density was similar