Based on the results of researches and applications for many years, it has been discovered that new methods and techniques for geochemical exploration of oil and gas such as AC, altered carbonate, Hg in absorption phase, Ks, Fe2+ ,δ13C, fluorescence in two and three dimensions, and N2 and O2 in heat release can give full play in the following five fields: (1) optimization of the favourable target or hollow zones and structural zones in a region; (2) evaluation of oil traps and delineation of prospective oil and gas areas; (3) prediction of deep-seated oil-bearing horizons; (4) evaluation of the genesis of oil and gas geochemical anomalies and determination of the types of oil and gas accumulations; (5) forecast of the burial depths of oil and gas pools. Based on the results of researches and applications for many years, it has been discovered that new methods and techniques for geochemical exploration of oil and gas such as AC, altered carbonate, Hg in absorption phase, Ks, Fe2 +, δ13C, fluorescence in two and three dimensions, and N2 and O2 in heat release can give full play in the following five fields: (1) optimization of the favourable target or hollow zones and structural zones in a region; (2) evaluation of oil traps and delineation of prospective oil (3) prediction of deep-seated oil-bearing horizons; (4) evaluation of the genesis of oil and gas geochemical anomalies and determination of the types of oil and gas accumulations; (5) forecast of the burial depths of oil and gas pools.