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0引言重复观测数据（repeatedmeasuresdata）是预防医学和临床医学研究中十分常见的一种数据形式「‘．在实际工作中经常遇到重复测量因素是时间且取值等距的情况．当时间为重复因素时，由于序列相关等原因，这类数据资料进行一元方差分析时，其协方差阵常不满足统计学理论上的
0 INTRODUCTION Repeated measurements data is a very common form of data in preventive and clinical medicine research. "’. In practice, it is often the case that repeated measurement factors are time and values are equidistant. When the time is repeated When factors, due to sequence correlation and other reasons, when this type of data is analyzed by one-way analysis of variance, the covariance matrix often does not satisfy the statistical theory.