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急性和慢性金属中毒的治疗,通常是利用络合剂治疗。本文介绍了一种复合配位体螯合剂的治疗方法。在这种疗法中,金属与两种或两种以上的螯合剂结合,因而提高了金属螯合物的稳定性。作者选用出生45天,体重为25.1±0.6g的雌性小鼠。尾静脉注射放射性~(289)钚的1%枸橼酸钠溶液或放射性~(109)镉与氯化镉的混合溶液。~(289)钚和~(109)镉的放射化学测定是用湿组织灰分和排泄物,并用液体闪烁计数器进行测定。临用前混合复合配位体螯合剂。治疗剂量按mM/kg计算,每周治疗两次,腹腔内注射。实验性钚中毒的治疗:每只小鼠尾静脉注射0.0162μCi(即微居里) ~(289)钚,3天后几乎全部的
Acute and chronic metal poisoning treatment, usually using complexing agent. This article describes the treatment of a complex ligand chelator. In this therapy, the metal is combined with two or more chelating agents, thereby increasing the stability of the metal chelate. The authors used 45-day-old, 25.1 ± 0.6g body weight female mice. Tail vein injection of radioactive ~ (289) plutonium 1% sodium citrate solution or radioactive ~ (109) a mixed solution of cadmium and cadmium chloride. The radiochemical determination of ~ (289) plutonium and ~ (109) cadmium was performed using wet tissue ash and excrement and was measured using a liquid scintillation counter. Before use mixed complex ligand chelator. Treatment dose in mM / kg, twice weekly treatment, intraperitoneal injection. Treatment of Experimental Plutonium Poisoning: 0.0162 μCi (ie, microcarrier) ~ (289) plutonium was injected into the tail vein of each mouse and almost all