论文部分内容阅读
抗结核药物体液浓度测定,对了解药物代谢情况、制定给药方案以稳定病人的血药浓度、减少毒副反应、提高治疗效果有极其重要的意义。现将用可见及紫外分光光度法测定几种常用抗结核药物体液浓度的有关资料综述如下。异烟肼(INH) 用可见或紫外分光光度法测定INH的体液浓度在国内外都有不少报道。 Peters等测定尿中INH和对酸不稳定的INH衍生物的方法是:1ml样品、空白管和含INH1μg/ml的标准管,同样用2ml 0.2mol/L HCl酸化。在加入0.2ml 2％
Determination of body fluid concentration of anti-TB drugs, to understand the drug metabolism, the formulation of drug delivery programs to stabilize the patient’s plasma concentration, reduce side effects, improve the treatment effect is extremely important. The relevant data on the concentrations of body fluids of several commonly used anti-TB drugs, both visible and UV-spectrophotometric, are summarized below. Isoniazid (INH) Determination of INH body fluid concentration by visible or UV spectrophotometry at home and abroad have a lot of reports. The method used by Peters et al. To determine INH in urine and INH derivatives that are acid-labile is: 1 ml sample, blank tube and standard tube containing INH 1 μg / ml, also acidified with 2 ml 0.2 mol / L HCl. After adding 0.2 ml of 2%