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目的观察白介素-2联合平阳霉素治疗恶性胸腔积液的疗效和不良反应。方法恶性肿瘤合并胸腔积液者,用中心静脉导管行闭式引流,胸腔内注入白介素-2、平阳霉素,每周注药1～2次,3～4次为1个疗程。结果 38例患者中CR28例,PR5例,有效率86.8%,生活质量改善,少数病例轻微发热、胸痛。结论胸腔内注射白介素-2、平阳霉素治疗恶性胸腔积液,疗效好,不良反应小,易为患者接受。
Objective To observe the efficacy and adverse reactions of interleukin-2 combined with pingyangmycin in the treatment of malignant pleural effusion. Methods Malignant tumors with pleural effusion who closed drainage with central venous catheter, intrapleural injection of interleukin -2, pingyangmycin injection 1 to 2 times a week, 3 to 4 times for a course of treatment. Results Among the 38 patients, 28 cases were CR and 5 cases were PR. The effective rate was 86.8%. The quality of life improved. A few cases had mild fever and chest pain. Conclusions Intrapleural injection of interleukin-2 and pingyangmycin in the treatment of malignant pleural effusion has good curative effect and small adverse reaction, which is easy for patients to accept.