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目的 :探讨谷胱甘肽过氧化物酶 (GSH PX)在新生儿缺氧缺血性脑病 (HIE)中的变化及其意义。方法 :通过用酶促反应谷胱甘肽的消耗 ,求出酶的活力 ,测定 40例新生儿HIE患儿和 15例正常新生儿血浆GSH PX水平及 36例HIE患儿脑脊液GSH PX水平。结果 :HIE患儿急性期血浆GSH PX低于对照组 (P <0 0 5 ) ,且随着HIE程度加重而降低 ;中、重度HIE急性期与恢复期比较均具有统计学意义 (P <0 0 1) ;HIE患儿CT异常组血浆和脑脊液GSH PX水平均低于HIE者的CT正常组 ;血浆与脑脊液GSH PX间呈正相关关系。结论 :GSH PX参与了HIE的病理过程 ,在HIE病程中对脑损伤可能具有一定保护作用
Objective: To investigate the changes of glutathione peroxidase (GSH-PX) in neonatal hypoxic-ischemic encephalopathy (HIE) and its significance. Methods: The activity of GSH PX was determined by enzymatic glutathione consumption. Plasma GSH PX levels were measured in 40 neonates with HIE and 15 normal neonates and GSH PX levels in 36 children with HIE. Results: The plasma levels of GSH PX in acute stage of HIE patients were lower than those in control group (P <0 05), and decreased with the increase of HIE degree. The acute and recovery stages of moderate and severe HIE were statistically significant (P0.01) 0 1). The levels of GSH PX in plasma and cerebrospinal fluid in CT abnormalities group were lower than those in normal HIE group, and there was a positive correlation between GSH and PX in plasma and cerebrospinal fluid. Conclusion: GSH PX is involved in the pathological process of HIE and may have a protective effect on brain injury during the course of HIE