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目的:探究短期雾化吸入低剂量糖皮质激素在老年慢性阻塞性肺疾病急性加重(AECOPD)合并陈旧肺结核治疗中应用价值。方法:随机选出我院2015年6月~2016年9月50例老年AECOPD合并陈旧肺结核患者,分为对照组和吸入组,对照组患者采用常规的治疗方法,吸入组采取短期雾化吸入低剂量糖皮质激素,对比两组患者的肺功能指标、血清水平相关指标变化。结果:两组患者治疗后和治疗前相比,患者的肺功能得到显著性的改善(P<0.05),另外血清中的IL-8和TNF-a指标显著性降低(P<0.05);和对照组患者相比,吸入组患者的肺功能指标、血清水平指标改善效果更为显著,对比P<0.05。结论:通过短期雾化吸入低剂量糖皮质激素治疗老年AECOPD合并陈旧肺结核疾病,可以有效的改善患者的肺功能,有效降低患者血清中的IL-8和TNF-a指标,进而有助于尽早缓解患者的症状,并缩短住院病程。
Objective: To explore the value of short-term inhalation of low dose glucocorticoid in the treatment of elderly patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) and old tuberculosis. Methods: Fifty elderly AECOPD patients with old pulmonary tuberculosis were randomly selected from June 2015 to September 2016 in our hospital. Patients in control group and inhalation group were given routine treatment. Patients in inhalation group were treated with short-term atomization inhalation Dose of glucocorticoid, lung function of patients compared two groups of indicators, serum levels related indicators. Results: Compared with before treatment, the lung function of patients in both groups improved significantly (P <0.05) and IL-8 and TNF-α in serum decreased significantly (P <0.05); and Compared with the control group, the pulmonary function indexes and the serum level indexes of the patients in inhalation group were more obviously improved, P <0.05. CONCLUSIONS: Short-term inhalation of low-dose glucocorticoid therapy for senile AECOPD with obsolete pulmonary tuberculosis can effectively improve lung function and reduce serum IL-8 and TNF-a levels in patients with advanced AECOPD, thus contributing to early remission The patient’s symptoms and shorten the duration of hospitalization.