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目的 :CARBO 3 0 0mg/m2 静脉滴入 ,d1;PDD 2 5mg/m2静脉滴入 ,d2～ 5;5 FU 5 0 0mg/m2 静脉滴入 ,d1～ 4,2 8d为 1周期 ,治疗 2～ 3周期后评价疗效。CR为 3 2 8% (19/ 5 8) ,PR为 5 0 0 % (2 9/ 5 8) ,CR +PR为 82 8% (4 8/ 5 8) ;转移淋巴结有效率 87 9% (5 1/ 5 8) ;吞咽困难有效率 80 %。毒副反应主要为恶心、呕吐 ,发生率 69 0 % (4 0 / 5 8) ,其中 3～ 4级为 41 4% (2 4/5 8) ;血液学毒性为中性粒细胞下降 ,2～ 3级者 2 9 3 % (17/ 5 8) ,无 4级者 .结论 :CPF方案是治疗中晚期食管癌的有效方案 ,值得推广应用
Objective: CARBO300mg / m2 intravenous drip, d1; PDD25mg / m2 intravenous drip, d2 ~ 5; 5 FU50mg / m2 intravenous drip, d1 ~ 4,28d for the 1 cycle, treatment 2 ~ 3 cycles after the evaluation of efficacy. CR was 32.8% (19/58), PR was 500% (29/58), and CR + PR was 82.8% (48/58). The effective rate of metastatic lymph nodes was 87.9% 5 1/5 8); difficulty swallowing 80% effective. The main side effects were nausea and vomiting. The incidence rate was 69 0% (40/58), of which 41 4% (4 4/5 8) in grade 3 to 4; hematologic toxicity was neutrophil decreased 2 ~ 3 grade 2 93% (17/58), no grade 4. Conclusion: CPF program is an effective treatment of advanced esophageal cancer program, it is worth to promote the use of