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目的探讨乳腺癌术前中医证型与病理组织学分级,临床分期,雌激素受体(ER),孕激素受体(PR)以及表皮生长因子受体(C-erbB-2)表达的相关性。方法对78例确诊为乳腺癌的患者术前进行中医辨证分型.术后进行临床分期,手术标本行病理检查,并检测ER、PR及C-erbB-2表达,进行分析。结果三个证型间比较,ER、PR表达无显著性差异,肝郁痰凝型TNM分期早,病理组织学分级低,C-erbB-2表达阳性率低,而正虚毒炽型TNM分期晚,病理组织分级高,C-erbB-2表达阳性率高,且差异有统计学意义(P<0.05)。结论乳腺癌中医证型与TNM分期,病理组织学分级以及C-erbB-2蛋白表达等预后因素之间有相关性,三个证型中,肝郁痰凝型预后最好,正虚毒炽型预后最差。
Objective To investigate the correlation between preoperative TCM syndrome types and histopathological grade, clinical stage, expression of estrogen receptor (ER), progesterone receptor (PR) and epidermal growth factor receptor (C-erbB-2) . Methods 78 cases diagnosed as breast cancer were pretreated with TCM syndrome differentiation.All patients were followed up for clinical staging and surgical specimens for pathological examination, and the expressions of ER, PR and C-erbB-2 were detected and analyzed. Results There was no significant difference in expression of ER and PR between the three syndromes. The TNM staging of liver-qi and phlegm-condensing type was earlier, the pathological grade was lower, the positive rate of C-erbB-2 expression was lower, Later, the histopathological grade was high, the positive rate of C-erbB-2 expression was high, and the difference was statistically significant (P <0.05). Conclusion There is a correlation between TCM syndromes of breast cancer and the prognosis of TNM staging, histopathological grade and C-erbB-2 protein expression. Among the three syndromes, the syndrome of liver depression and phlegm coagulation has the best prognosis, The worst prognosis.