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读了祝惠民同志对拙作《有机磷中毒恢复期的反跳与猝死》一文提出的意见,甚受启发。现将ChE直接抑制剂问题,谈点看法: ①ChE直接抑制剂代谢是否经过肝脏?事实证明:凡是经口进入的毒物吸收后,首要经过肝脏,其他途径进入的则先经大循环再转到肝脏。ChE直接抑制剂可不经肝脏氧化就发挥毒性作用,这是指在血液中有些化学活性较大的物质可以在循环时就发生化学反应,但这种“直接”的概念并不意味它不再经过肝脏转化代谢就完全或毫无变化的排出体外。②ChE直接抑制剂是否转化增毒。以“意见一文”所例举的敌百虫为例,它虽然可以不经肝脏氧化就直接发生毒性作用,但还需经过脏肝转化,尚可脱去氯化氢形成
After reading Comrade Zhu Huimin’s myopia’s article entitled “Rebound and Sudden Death in the Recovery Period of Organophosphorus Poisoning,” I was greatly inspired. Now ChE direct inhibitors, talk about the point of view: ①ChE direct inhibitor of metabolism whether through the liver? It turns out: All orally absorbed intoxication, the first through the liver, other ways to enter the first cycle and then go to the liver . ChE direct inhibitors can act toxic without liver oxidation, which means that some of the more chemically active substances in the blood can react chemically during circulation, but this “direct” notion does not mean that it does not pass any further Metabolism of the liver on the complete or no change excreted. ② whether direct conversion of CHE is toxic or not. Take the example of trichlorfon exemplified in the Opinion article. Although it can directly cause toxic effects without liver oxidation, it needs to be converted into dirty liver and can take off hydrogen chloride