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目的通过测定急性脑梗死D-二聚体(D-Dimer)含量的变化,为进一步了解急性脑梗死病理生理机制、病程判断及疗效观察提供试验依据。方法对30例急性脑梗死患者和20例正常人用Elisa法测定血浆D-二聚体(D-Dimer)含量。结果急性脑梗死患者急性期血浆D-二聚体含量较正常人明显升高(P<0.01),恢复期下降,急性期和恢复期比较有显著差异(P<0.01)。结论提示急性脑梗死患者急性期呈高凝状态的表现,血浆D-二聚体动态测定可作为急性脑梗死病程判断及疗效观察的有用的指标。
Objective To determine the changes of D-dimer in patients with acute cerebral infarction and provide experimental basis for further understanding of the pathophysiological mechanism, course of disease judgment and curative effect of acute cerebral infarction. Methods Thirty patients with acute cerebral infarction and 20 normal subjects were tested for plasma D-dimer by Elisa method. Results The level of plasma D-dimer in patients with acute cerebral infarction was significantly higher than that in healthy people (P <0.01), and the recovery period was decreased. There was significant difference between acute phase and recovery phase (P <0.01). The results suggest that acute cerebral infarction patients showed hypercoagulable state in acute phase. The dynamic measurement of plasma D-dimer can be used as a useful indicator to judge the course of acute cerebral infarction and observe the curative effect.