In recent years,growing interest has been focused on the field of cancer prevention.Cancer prevention by chemopreventive agents offers significant promise for re-ducing the incidence and mortality of cancer.Chemopreventive agents may exerttheir effects either by blocking or metabolizing carcinogens or by inhibiting tumorcell growth.Another important benefit of chemopreventive agents is their non-toxic nature.Therefore,chemopreventive agents have recently been used forcancer treatment in combination with chemotherapeutics or radiotherapy,uncov-ering a novel strategy for cancer therapy.This strategy opens a new avenue fromcancer prevention to cancer treatment.In vitro and in vivo studies have demon-strated that chemopreventive agents could enhance the antitumor activity ofchemotherapeutics,improving the treatment outcome.Growing evidence hasshown that chemopreventive agents potentiate the efficacy of chemotherapy andradiotherapy through the regulation of multiple signaling pathways,includingAkt,NF-kB,c-Myc,cyclooxygenase-2,apoptosis,and others,suggesting amultitargeted nature of chemopreventive agents.However,further in-depth mecha-nistic studies,in vivo animal experiments,and clinical trials are needed to investi-gate the effects of chemopreventive agents in combination treatment of cancerwith conventional cancer therapies.More potent natural and synthetic chemo-preventive agents are also needed to improve the efficacy of mechanism-basedand targeted therapeutic strategies against cancer,which are likely to make asignificant impact on saving lives.Here,we have briefly reviewed the role ofchemopreventive agents in cancer prevention,but most importantly,we havereviewed how they could be useful for cancer therapy in combination with con-ventional therapies. Cancer growth has been focused on the field of cancer prevention. Cancer prevention by chemopreventive agents offers significant promise for re-ducing the incidence and mortality of cancer. Chemopreventive agents may exert the effects either by blocking or metabolizing carcinogens or by inhibiting tumor cells growth. Another important benefit of chemopreventive agents is their non-toxic nature. Before, chemopreventive agents have recently been used for cancer treatment in combination with chemotherapeutics or radiotherapy, uncov-ering a novel strategy for cancer therapy. This strategy opens a new avenue from cancer prevention to cancer treatment. vitro and in vivo studies have demon-strated that chemopreventive agents could enhance the antitumor activity ofchemotherapeutics, improving the treatment outcome. Growth evidence hasshown that that chemopreventive agents potentiate the efficacy of chemotherapy andradiotherapy through the regulation of multiple signaling pathways, inclu dingAkt, NF-kB, c-Myc, cyclooxygenase-2, apoptosis, and others, prompted amultitargeted nature of chemopreventive agents. Even in-depth mecha-nistic studies, in vivo animal experiments, and clinical trials are needed to investi- gate the effects of chemopreventive agents in combination treatment of cancer with conventional cancer therapies. More potent natural and synthetic chemo-preventive agents are also needed to improve the efficacy of mechanism-based and targeted therapeutic strategies against cancer, which are likely to make asignificant impact on saving lives.Here, we have briefly reviewed the role of chemopreventive agents in cancer prevention, but most importantly, we havereviewed how they could be useful for cancer therapy in combination with con -ventional therapies.