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p27是细胞周期蛋白依赖性激酶抑制剂(CDKI)家族中的重要成员,能阻滞细胞进入G1期或S期,其蛋白表达水平及活性改变与肿瘤发生发展有关。p27基因存在多个单核苷酸多态性(SNPs)位点,其中p27Val109Gly(rs2066827)基因多态性位于其降解蛋白Jab1结合区,导致p27与降解蛋白Jab1的不同结合活性,从而影响其在肿瘤发生发展中的作用,因此被认为是p27基因最重要的多态性。本文拟综述p27Val109Gly基因多态性在肿瘤发生发展中的分子机制。
p27 is an important member of cyclin-dependent kinase inhibitor (CDKI) family and can block cell entry into G1 or S phase. The expression of p27 and its activity are related to tumorigenesis. There are many SNPs in p27 gene, of which the p27Val109Gly (rs2066827) gene is located in the Jab1 binding region, which leads to the different binding activity between p27 and degradation protein Jab1, Therefore, it is considered as the most important polymorphism of p27 gene. This article is to review the molecular mechanism of p27Val109Gly polymorphism in tumorigenesis.