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目的：探讨慢性缺氧和营养不良对膈肌功能和膈肌肌电图（ＥＭＧｄｉ）的影响以及复方红景天对膈肌功能的保护作用。方法：将３２ 只Ｗｉｓｔａｒ大鼠随机分为慢性缺氧组（放入常压缺氧箱内，氧浓度０．１１０±０．００５，每日８ 小时，Ａ 组）、营养不良组（每日进正常食量的１／２，Ｂ组）、缺氧加复方红景天组（缺氧方法同Ａ组，每日缺氧前灌服复方红景天１．０ ｇ／ｋｇ，Ｃ组）和正常对照组（Ｄ组），每组８只。实验５ 周在麻醉下测体重、ＥＭＧｄｉ和膈肌功能；动物处死后测膈重。结果：Ｂ组体重低于Ａ、Ｃ、Ｄ组５０％ ，膈肌显著变薄，面积缩小，重量减轻；Ａ、Ｂ组ＥＭＧｄｉ的高频份量与低频份量比值（Ｈ／Ｌ）、中心频率（Ｆｃ）和电刺激时膈肌最大收缩力、最大强直收缩、疲劳指数均较Ｃ、Ｄ组显著降低；强直收缩时间和疲劳时间较Ｃ、Ｄ组显著缩短，Ａ组与Ｃ、Ｄ组，Ｂ组与Ｃ、Ｄ组之间比较均有非常显著性差异（Ｐ均＜ ０．０１）；Ａ组与Ｂ组、Ｃ组与Ｄ组比较则无显著性差异。结论：慢性缺氧和营养不良能明显引起膈肌疲劳；复方红景天对缺氧性膈肌疲劳具有明显保护作用。
Objective: To investigate the effects of chronic hypoxia and malnutrition on diaphragmatic muscle function and EMGdi and the protective effect of compound Rhodiola on diaphragmatic function. Methods: Thirty-two Wistar rats were randomly divided into chronic hypoxia group (normal pressure hypoxia chamber, oxygen concentration 0.110 ± 0.005, 8 hours a day, group A), malnourished group Into the normal food intake 1/2, B group), hypoxia combined with Rhodiola group (hypoxia method with A group, daily hypoxia fed compound Rhodiola 1.0 g / kg, C group) and Normal control group (D group), each group of 8. Body weight, EMGdi and diaphragmatic function were measured under anesthesia for 5 weeks. Diaphragmatic weight was measured after the animals were sacrificed. Results: The body weight of group B was lower than that of group A, C and D by 50%, the diaphragm was significantly thinner, the area was reduced and the weight was reduced. The ratio of high frequency to low frequency (H / L) and center frequency ), And maximal contractile force, maximal tetanus contractility and fatigue index were significantly lower than those in C and D group. Contraction time and fatigue time were significantly shorter than those in C and D group. A group, C, D group, B group and There was significant difference between C and D groups (P <0.01). There was no significant difference between A group and B group, C group and D group. Conclusion: Chronic hypoxia and malnutrition can cause diaphragmatic fatigue obviously. Compound rhodiola has obvious protective effect on hypoxic diaphragmatic fatigue.