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应用光化学原位聚合法合成了聚(甲基丙烯酸二乙氨基乙酯)包覆的磁性纳米凝胶(PDEA-磁性纳米凝胶).应用傅里叶变换红外光谱(FTIR)、热重分析仪(TGA)、振动样品磁强计(VSM)、光子相关光谱(PCS)等对PDEA-磁性纳米凝胶的结构、形貌、磁学性质、粒径及表面ζ-电位等进行了表征.结果表明,PDEA-磁性纳米凝胶形状较规则,为“核-壳”结构,表面PDEA高分子层约为26%,平均水合粒径为43nm,具有超顺磁性.该磁性纳米凝胶具有明显的pH敏感性,在室温、pH5.0时可结合DNA分子,最大结合量为51μg/mg,在pH7.4条件下能够将DNA高效释放出来,且呈现出明显的缓释效应,加之良好的磁响应性能,使其可作为一种新型磁靶向转基因载体应用于生物医学研究.
(PDEA-magnetic nano-gel) coated with poly (diethylaminoethyl methacrylate) was synthesized by photochemical in-situ polymerization.FTIR, FTIR, (TGA), vibrating sample magnetometer (VSM) and photon correlation spectroscopy (PCS) were used to characterize the structure, morphology, magnetic properties, particle size and surface ζ-potential of PDEA- The results showed that the PDEA-magnetic nanogels had a regular shape of “core-shell” with a surface layer of about 26% PDEA polymer and an average hydrated size of 43nm with superparamagnetism.The magnetic nanogels had Significant pH sensitivity, at room temperature, pH5.0 can bind to DNA molecules, the maximum binding capacity of 51μg / mg, at pH7.4 under the conditions of DNA can be efficiently released, and showed a sustained release effect, combined with good Magnetic response properties, making it a novel magnetic targeting gene delivery vector for biomedical research.