Ｗｅｒｎｉｃｋｅ脑病是ＶｉｔＢ１缺乏所致的中枢神经系统疾患,临床上较罕见。本院最近收住一名ＣＯＰＤ并发该病的患者,特此报告。病例报告患者男性,６５岁,反复咳嗽、咯痰２０年,活动后胸闷、气促１０年。痰呈黄色脓性,量多,乏力明显。５月前曾有类似症状,在当地医院诊为“? Wernicke encephalopathy is a central nervous system disorder caused by VitB1 deficiency, which is clinically rare. We recently admitted to a COPD patients with the disease, hereby report. Case Report Male patients, 65 years old, repeated cough, expectoration 20 years, chest tightness after activities, shortness of breath 10 years. Phlegm yellow purulent, the amount of more obvious fatigue. There was a similar symptom before May, which was diagnosed in the local hospital as “?”