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瞬时受体电位阳离子通道蛋白6(TRPC6)是新近发现的肾小球足细胞分子,定位于足细胞裂孔隔膜,与nephrin、podocin和CD2AP存在共定位分布,共同参与信号转导,并维持足细胞正常的结构和功能。TRPC6基因突变可以导致常染色体显性家族性局灶节段性肾小球硬化,患者表现为大量蛋白尿和足细胞损伤,体外试验也表明其高表达可通过增加钙离子内流损伤足细胞,说明TRPC6与蛋白尿的发生、发展密切相关。现将阐明TRPC6在足细胞损伤中的作用,有望为肾脏病的诊断和治疗提供新的靶点。
Transient receptor potential cation channel protein 6 (TRPC6) is a recently discovered glomerular podocyte molecule localized in the podiatric compartment and co-localized with nephrin, podocin, and CD2AP, participating in signal transduction and maintaining podocyte Normal structure and function. TRPC6 gene mutations can lead to autosomal dominant focal segmental glomerulosclerosis, the patient showed a large number of proteinuria and podocyte injury in vitro experiments also showed that high expression of calcium ions can increase the influx of podocytes injury, Description TRPC6 and proteinuria are closely related to the development. The role of TRPC6 in podocyte injury will now be elucidated, which is expected to provide a new target for the diagnosis and treatment of kidney disease.