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目的探讨神经节苷脂治疗胆红素脑病的疗效。方法对两组患儿均采用静注白蛋白免疫球蛋白,光照疗法蓝光,及纠正酸碱失衡电解质紊乱等治疗,按照患儿的情况选择照射时间,如果没有特殊需要,最好连续照射48~72 h,如果需要间断照射,则每4 h照1 h或者照射6~12 h后停止照射,在2~4个小时后继续照射。观察组在此基础上使用神经节苷脂,每天20 mg,7天为一个疗程。结果对照组的16名患儿有效率为62.5%;观察组的16名患儿有效率为93.8%。观察组的治疗效果明显高于对照组(P<0.05)。结论神经节苷脂对于新生儿胆红素脑病的治疗效果较好,并能够有效减轻后遗症,提高患儿的生活质量,目前尚未发现不良反应,值得临床上推广使用。
Objective To investigate the efficacy of ganglioside in the treatment of bilirubin encephalopathy. Methods The two groups of children were treated with intravenous albumin immunoglobulin, blue light therapy, and correction of electrolyte imbalance electrolyte therapy, according to the situation of children choose irradiation time, if there is no special need, the best continuous irradiation 48 ~ 72 h, if you need intermittent irradiation, then every 4 h according to 1 h or irradiation 6 ~ 12 h after the irradiation stopped, 2 to 4 hours after irradiation continued. The observation group used gangliosides on the basis of 20 mg daily for 7 days. Results The effective rate of 16 children in the control group was 62.5%. The effective rate of the 16 children in the observation group was 93.8%. The treatment effect of the observation group was significantly higher than that of the control group (P <0.05). Conclusion Gangliosides are effective in treating neonatal bilirubin encephalopathy and can effectively reduce the sequelae and improve the quality of life in children. No adverse reactions have been found so far, and it is worth to be used clinically.