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何杰金氏病又称淋巴网状细胞瘤,是恶性淋巴瘤的一种。其组织学特点是淋巴细胞和网状细胞都显著增生,并出现具有特征性的Reed-Sternberg多核巨细胞(又称巨网细胞)。自Thomas Hodgkin于1832年首次描述此病以来,只是在近10余年,其预后才有了较显著的改观,这与应用新的诊断技术(如淋巴造影、剖腹探查与脾切除术)使分期更为准确,从而使治疗方案更为恰当,以及治疗方法上应用超高压X射线、大照射野放疗和以MOPP为代表的联合化疗有关。当然,以上诊断和治疗措施本身都有较严重的并发症,尤其对正在生长发育的小儿影响更大,有待进一步研究解决。
Hodgkin’s disease, also known as lymphocytoma, is a type of malignant lymphoma. Its histological features are marked proliferation of lymphocytes and reticular cells, and the appearance of characteristic Reed-Sternberg multinucleated giant cells (also known as giant mesh cells). Since Thomas Hodgkin first described the disease in 1832, only in the last 10 years, the prognosis has improved significantly. This is in line with the application of new diagnostic techniques (such as lymphography, laparotomy and splenectomy). To be accurate, so that the treatment program is more appropriate, and the use of ultra-high pressure X-ray therapy, radiation therapy and radiotherapy as the representative of the combination of chemotherapy. Of course, the above diagnostic and therapeutic measures have serious complications in themselves, especially for children who are growing and developing, and need to be further studied and solved.