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研究发现在碱性条件下,纳米银对鲁米诺-铁氰化钾液相化学发光体系发光信号具有明显的增敏作用,而4-乙酰氨基酚对该体系具有强烈的抑制作用。结合流动注射技术,建立了流动注射化学发光分析法测定对乙酰氨基酚的新方法。该方法测定对乙酰氨基酚的线性范围为9.0×10-12～1.0×10-10g/mL(0.9947)和1.0×10-10～7.0×10-9g/mL(0.9904),检出限(3σ)为7.9×10-12g/mL。对5.0×10-11g/mL和5.0×10-10g/mL对乙酰氨基酚平行测定11次,其相对标准偏差为1.3%和1.3%。该方法用于片剂中对乙酰氨基酚的测定,回收率为97.0%～101.5%。
The results showed that under alkaline conditions, nano-silver has a significant sensitizing effect on the luminescence signal of the luminol-potassium ferricyanide liquid chemiluminescence system, and 4-acetaminophen has a strong inhibitory effect on the system. A new method for the determination of paracetamol by flow injection chemiluminescence was established by combining with flow injection technique. The linear range of acetaminophen was 9.0 × 10-12 ~ 1.0 × 10-10g / mL (0.9947) and 1.0 × 10-10 ~ 7.0 × 10-9g / mL (0.9904). The detection limit (3σ ) Was 7.9 × 10-12 g / mL. The relative standard deviations were 1.3% and 1.3% for 11 determinations of 5.0 × 10-11 g / mL and 5.0 × 10 -10 g / mL paracetamol in parallel. The method was applied to the determination of paracetamol in tablets with the recovery of 97.0% ~ 101.5%.