人类降钙素(CT)分泌最显著的特点之一是明显的两性差异。这使人推测健康妇女血浆CT的相对不足可能是绝经后骨脱钙的一个病因。因为CT的一个主要生理功能似是对抗1,25(OH)_2D和甲状旁腺激素(PTH)的骨钙再吸收作用来防止骨骼过度吸收。至少在妇女,性激素可能参与CT分泌的调节。作者报告二组绝经后妇女用雌激素治疗前后血浆CT和钙调节激素水平测定结果以及雌激素治疗对逆转雌激素缺乏的作用。 One of the most salient features of human calcitonin (CT) secretion is the pronounced gender difference. This led one to speculate that the relative lack of plasma CT in healthy women may be a cause of decalcification of postmenopausal bone. Because one of the major physiological functions of CT appears to be to prevent bone resorption over bone resorption of 1,25 (OH) 2D and parathyroid hormone (PTH). At least in women, sex hormones may be involved in the regulation of CT secretion. The authors report the results of the plasma CT and calcium-regulated hormone levels before and after treatment with estrogen in postmenopausal women and the effect of estrogen therapy on reversing estrogen deficiency.