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目的:探讨小剂量平阳霉素早期治疗婴幼儿口腔颌面部血管瘤的临床疗效。方法:收集2004年6月—2009年6月应用小剂量平阳霉素注射治疗的婴幼儿口腔颌面部血管瘤82例。平阳霉素浓度为1～1.6g/L,每次注射剂量不超过4mg,用药总量一般不超过20mg,根据患儿的年龄、瘤体大小和深度决定用药浓度、剂量和注射次数。血管瘤进入消退期则停止治疗,随访6～24个月。随访时间最长4a,最短6个月。采用SPSS13.0软件包对瘤体直径≥2cm者与<2cm者的疗效进行χ2检验。结果:治愈58例(70.73%),基本治愈21例(25.61%),好转3例(3.66%),未见无效病例。治愈和基本治愈率合计为96.34%,有效率为100%。统计学分析表明,疗效与瘤体大小无显著相关性。3例病例出现注射部位溃疡、皮肤坏死,继而结痂,痂皮脱落后遗留浅表瘢痕。4例注射后食欲缺乏。无腮腺分泌障碍和面神经损伤症状;未发现肺纤维化或生长抑制现象。结论:小剂量平阳霉素早期治疗血管瘤的疗效显著,不良反应较少,具有远期美容效果,为目前治疗婴幼儿口腔颌面部血管瘤的有效方法之一,值得推广应用。
Objective: To investigate the clinical efficacy of low-dose pingyangmycin in the early treatment of oral and maxillofacial hemangiomas in infants and young children. Methods: Totally 82 cases of oral and maxillofacial hemangiomas were treated in our hospital from June 2004 to June 2009 with low dose pingyangmycin injection. Pingyangmycin concentration of 1 ~ 1.6g / L, each injection dose does not exceed 4mg, the total amount of medication is generally not more than 20mg, according to children’s age, tumor size and depth of drug concentration, dosage and number of injections. Hemangiomas into the regression period to stop treatment, followed up for 6 to 24 months. The longest follow-up 4a, the shortest 6 months. SPSS13.0 software package on the tumor diameter ≥ 2cm who and <2cm curative effect of the χ2 test. Results: 58 cases (70.73%) were cured, 21 cases (25.61%) were basically cured, 3 cases (3.66%) were cured, and no invalid cases were found. The cure rate and the basic cure rate are 96.34% and the effective rate is 100%. Statistical analysis showed no significant correlation between efficacy and tumor size. Three cases of ulcers at the injection site, skin necrosis, followed by scabs, scabs left after the superficial scar. 4 cases of loss of appetite after injection. No parotid secretory disorders and facial nerve injury symptoms; no signs of pulmonary fibrosis or growth inhibition. Conclusions: The early treatment of hemangiomas with low-dose pingyangmycin is effective and has few side-effects and long-term cosmetic effects. It is one of the effective methods for the treatment of oral and maxillofacial hemangiomas in infants.