Background Few studies with small sample sizes have investigated the correlations between related factors and aortic dissection(AD) complications. There is lack of systematic observation on type or stage specific AD patients, such as the Stanford type B acute aortic dissection(AAD) patients with high risk of complications in hospital. Methods We registered consecutive 105 Stanford type B AAD patients, and the admission day were less than 2 weeks of onset. The correlations of major complications with general clinical information, laboratory tests and treatments were analyzed. Result Among 105 cases of Stanford type B AAD patients, 46.7% cases had major complications and 8.6% patients died. The Receiver Operating Characteristic curve(ROC curve) analysis showed that the D-dimer > 500 μg/L was the best cut-off value to predict major complications(sensitivity 67%,specificity 79%, C-statistic was 0.69, P = 0.001). In the univariate analysis of related factors for major complications, the D-dimer > 500 μg/L(P = 0.0001), NT-pro BNP(P = 0.048), Scr(P = 0.039), age ≥ 60 year(P =0.012), history of hypertension and endovascular aortic repair(EVAR) in combination with carotid artery bypass(CAB)(P = 0.027)had statistically significant. After adjusting for other predictors of major complications, Logistic regression analysis revealed that the D-dimer > 500 μg/L(odds ratio: 6.14, 95% confidence interval: 1.94-19.1,P = 0.002) and age ≥ 60 years(odds ratio:4.074, 95% confidence interval: 1.252-13.259, P = 0.02] were independent risk factors. While EVAR(odds ratio: 0.181, 95% confidence interval: 0.34-0.968, P = 0.046) and EVAR in combination with CAB treatments(odds ratio: 0.123, 95% confidence interval: 0.029-0.513, P = 0.004) were protective factors for major complications. Conclusion D-dimer > 500 μg/L and age≥60 years are independent risk factors for patients with in-hospital occurrence of major complications. While EVAR or EVAR combined CAB treatment can reduce the occurrence of major complications. Background Few studies with small sample sizes have investigated the correlations between related factors and aortic dissection (AD) complications. There is lack of systematic observation on type or stage specific AD patients, such as the Stanford type B acute aortic dissection (AAD) patients with Methods We registered consecutive 105 Stanford type B AAD patients, and the admission day were less than 2 weeks of onset. The correlations of major complications with general clinical information, laboratory tests and treatments were analyzed. Result Among 105 cases of Stanford type B AAD patients, 46.7% cases had major complications and 8.6% patients died. The Receiver Operating Characteristic curve (ROC curve) analysis showed that the D-dimer> 500 μg / L was the best cut-off value to predict major complications (sensitivity 67%, specificity 79%, C-statistic was 0.69, P = 0.001). In the univariate analysis of related factors for major complications, the D- history of hypertension and endovascular aortic repair (EVAR) in patients with dimer> 500 μg / L (P = 0.0001), NT-pro BNP (P = 0.048), Scr After adjusting for other predictors of major complications, Logistic regression analysis revealed that the D-dimer> 500 μg / L (odds ratio: 6.14, 95% confidence interval : Odds ratio: 0.181, 95% confidence interval: 1.94-19.1, P = 0.002) and age ≥ 60 years (odds ratio: 4.074, 95% confidence interval: 1.252-13.259, P = 0.02] : 0.34-0.968, P = 0.046) and EVAR in combination with CAB treatments (odds ratio: 0.123, 95% confidence interval: 0.029-0.513, P = 0.004) were protective factors for major complications. L and age ≥ 60 years are independent risk factors for patients with in-hospital occurrence of major complications. While EVAR or EVAR combined CAB treatment can reduce the occ urrence ofmajor complications.