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为探讨微卫星不稳定性在肾细胞癌的发生发展中的作用及其与临床病理指标的关系，建立了以ＰＣＲ 为基础的微卫星分析方法，选择分布在不同染色体上的１５ 个微卫星位点，共检测３４ 例新鲜肿瘤标本。３４ 例中有１５ 例（４４－１ ％ ）表现为微卫星不稳定性，并多见于晚期肿瘤（Ⅲ－ Ⅳ期）。结果提示微卫星不稳定性较广泛地存在于肾细胞癌中，可能与肿瘤发展有关。
To investigate the role of microsatellite instability in the development of renal cell carcinoma and its relationship with clinicopathological parameters, a microsatellite-based PCR-based method was developed to select 15 microsatellite loci on different chromosomes Point, a total of 34 cases of fresh tumor specimens were detected. Fifteen of 34 (44-1%) showed microsatellite instability and were more common in advanced tumors (stage III-IV). The results suggest that microsatellite instability is more commonly found in renal cell carcinoma, which may be related to tumor development.