慢性萎缩性胃炎与肠上皮化生(简称肠化)常同时存在,且发病颇为普遍,其病因、发病机制迄今尚未完全阐明。但因其与胃癌关系密切,多数学者将其作为胃癌癌前病变,故引起广泛重视。因此,对萎缩性胃炎与肠化的发病和防治的研究,对预防和减少胃癌的发病率具有重要意义。一、萎缩性胃炎病因与病理的研究:萎缩性胃炎的病因迄今不太明了,以往认为与自身免疫而产生的壁细胞抗体有关。但近年来以电镜作超微结构研究,发现不论萎缩性胃炎伴血清壁细胞抗体阳性或阴性患者,二者的超微结构均无显著差异,提示壁细胞抗体是胃粘膜损害的一种继发现象,而不是壁细胞损害的原因。亦有报告我国萎缩性胃炎壁细胞抗体低于 Chronic atrophic gastritis and intestinal metaplasia (referred to as intestinal metaplasia) often exist at the same time, and the incidence is quite common, its etiology, pathogenesis has not yet been fully elucidated. However, due to its close relationship with gastric cancer, most scholars regard it as a precancerous lesion of gastric cancer, so it has attracted widespread attention. Therefore, the study on the incidence and prevention of atrophic gastritis and intestinal metastasis is of great significance in preventing and reducing the incidence of gastric cancer. First, the cause and pathological study of atrophic gastritis: The cause of atrophic gastritis has hitherto been unclear. In the past, it was thought that there was a correlation with the parietal cells produced by autoimmunity. However, in recent years, ultrastructural studies using electron microscopy revealed that regardless of atrophic gastritis patients with positive or negative serum parietal cell antibodies, there was no significant difference in the ultrastructure between them, suggesting that parietal cell antibodies are secondary to gastric mucosal lesions. Phenomenon, not the cause of parietal cell damage. There have also been reports that atrophic gastritis antibody levels are below