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目的:探讨幽门螺杆菌(H.pylori)相关性慢性胃炎患儿胃窦黏膜炎症程度、H.pylori定植密度及其细胞毒素相关蛋白(CagA)三者之间的关系。方法:对79例H.pylori相关性慢性胃炎患儿行胃镜检查,取胃窦黏膜经HE及改良Giemsa染色后观察胃窦黏膜炎症程度及H.pylori定植密度,并采用免疫印迹法检测患儿血清CagA抗体。结果:63例胃窦黏膜中重度炎症患儿血清CagA抗体阳性58例(占92.06%),而16例胃窦黏膜轻度炎症患儿血清CagA抗体阳性9例(占56.25%),两者差异有显著性(χc2=10.076,P=0.002),而两组患儿胃窦黏膜H.pylori定植密度无明显差异(rs=0.097,P=0.394);胃窦黏膜不同H.pylori定植密度患儿血清CagA抗体检出率无明显差异(H=0.246,P=0.884)。结论:H.pylori相关性慢性胃炎患儿胃窦黏膜炎症程度与CagA有关,而与H.pylori在胃窦部的定植密度无相关,CagA阳性的H.pylori菌株能引起胃窦黏膜较重的炎症;H.pylori在胃窦部的定植密度与CagA无相关。
Objective: To investigate the relationship between the degree of gastric antral mucosal inflammation, the density of H.pylori colonization and its cytotoxic-related protein (CagA) in children with chronic gastritis associated with Helicobacter pylori infection. Methods: A total of 79 children with H.pylori-related chronic gastritis underwent gastroscopy. The antral mucosa was stained with HE and modified Giemsa to observe the degree of gastric inflammation and the density of H.pylori colonization. The immunocompromised children Serum CagA antibody. Results: Serum CagA antibody was positive in 58 cases (92.06%) of 63 patients with moderate and severe gastric mucosal inflammation, while serum CagA antibody was positive in 16 cases (56.25%) in 16 patients with mild inflammation of antral mucosa. (Χc2 = 10.076, P = 0.002). There was no significant difference in the density of H.pylori between the two groups (rs = 0.097, P = 0.394). There was no significant difference in the density of H.pylori between the two groups Serum CagA antibody detection rate was no significant difference (H = 0.246, P = 0.884). Conclusions: The degree of antral mucosal inflammation in children with chronic gastritis associated with H.pylori is related to CagA, but not with the density of H.pylori colonized in the gastric antrum. CagA-positive H.pylori strains can cause severe gastric mucosa Inflammation; H.pylori colonization density in the antrum and CagA no correlation.