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本研究采集750例妊娠妇女按自愿选择终止早孕的方法,比较药物(组Ⅰ、Ⅱ)与吸宫(组Ⅲ)的安全性、有效性、可接受性。三组治疗方案:①米非司酮首剂50mg,之后25mg/12h×4+PG05 1mg阴道塞药(组Ⅰ);②米非司酮同前+米索600μg(组Ⅱ);③吸宫流产(组Ⅲ)。结果显示:药流组与吸宫组完全流产率分别为94.2％(476/500)、100％(250/250),两组有显著性差异(P<0.001);不全流产率、失败率三个组分别为:2.4％和0、3.4％和0,组间有明显差异(P<0.01);出血量比月经量增多的对象占19.2％和10％,明显增多的占1.4％和0,组间有显著差异(P<0.05);出血持续时间为11.0±7.1和4.8±3.1,组间有显著差异(P<0.01);转经时间两种流产无统计学意义;两种流产的副反应,药流组的眩晕、下腹痛发生率高于手术组,而恶心、呕吐发生率低于手术组,两组间有显著性差异(P<0.01);对此次流产表示满意的药流组和吸宫组为:79.6％和84.4％,两组中分别有86.4％以及64.0％的对象在下一次发生意外妊娠时,仍然愿意采用本次选择的方法终止早孕。结果提示两种流产仍是目前终止早孕的最佳方法,药物流产作为终止早孕方法的补充是安全,有效、可接受的。
This study collected 750 pregnant women by voluntary choice to terminate early pregnancy method to compare the safety of drugs (Group Ⅰ, Ⅱ) and suction Palace (Group Ⅲ), the effectiveness and acceptability. Three groups of treatment options: ① first dose of mifepristone 50mg, then 25mg / 12h × 4 + PG05 1mg vaginal plug drug (group Ⅰ); ② mifepristone with the former + misoprostol 600μg (group Ⅱ); ③ suction Palace Abortion (Group III). The results showed that the rate of complete abortion was 94.2% (476/500) and 100% (250/250) respectively in the drug-flow group and the suction group, with significant difference between the two groups (P <0.001); incomplete abortion rate and failure rate Group had significant difference (P <0.01). The patients with bleeding volume increased by 19.2% and 10% respectively compared with those with menstrual flow increased by 1.4% and 0% respectively (P <0.05). The duration of hemorrhage was 11.0 ± 7.1 and 4.8 ± 3.1, there was a significant difference between the two groups (P <0.01). There was no significant difference between the two abortion cases (P <0.01). The rate of dizziness and lower abdominal pain in the drug-flow group was higher than that in the operation group, but the incidence of nausea and vomiting was lower than that in the operation group (P <0.01) Palace group was 79.6% and 84.4%, respectively, 86.4% of the two groups and 64.0% of the subjects in the next unwanted pregnancy, are still willing to use this method of choice to terminate early pregnancy. The results suggest that the two abortion is still the best method of termination of early pregnancy, abortion as a termination of early pregnancy method is safe, effective and acceptable.