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目的:探讨茵栀黄口服液对妊娠期肝内胆汁淤积症大鼠肝脏损伤的治疗作用。方法:取妊娠期大鼠48只,随机分成正常对照组,模型对照组,阳性对照组,茵栀黄口服液高、中、低剂量组。从妊娠期第12天开始肌内注射苯甲酸雌二醇2.5mg·kg-1·d-1,连续1周,同时按剂量灌胃给药。检测大鼠血清谷胱甘肽-S转移酶(GST)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)水平;并比较各组大鼠肝脏组织病理变化。结果:与模型对照组比较,茵栀黄口服液高、中、低剂量均可显著降低大鼠血清中GST、AST、ALT水平(P<0.01或0.05);并可显著缓解大鼠胆汁淤积状态下的肝损伤。结论:茵栀黄口服液对妊娠期肝内胆汁淤积症所导致的肝损伤有一定的治疗作用,具有较好的临床价值。
Objective: To investigate the therapeutic effects of Yinzhihuang Oral Liquid on liver damage in rats with intrahepatic cholestasis of pregnancy. Methods: 48 pregnant rats were randomly divided into normal control group, model control group, positive control group and Yinzhihuang oral liquid high, medium and low dose groups. From the 12th day of pregnancy intramuscular injection of estradiol benzoate 2.5mg · kg-1 · d-1 for 1 week, while the dose of oral administration. The serum levels of glutathione S-transferase (GST), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured. The histopathological changes in liver of the rats were compared. Results: Compared with the model control group, Yinzhihuang Oral Liquid could significantly reduce the levels of GST, AST and ALT (P <0.01 or 0.05), and significantly alleviate the cholestasis in rats Under the liver damage. Conclusion: Yinzhihuang Oral Liquid has a certain therapeutic effect on liver injury caused by intrahepatic cholestasis of pregnancy, and has good clinical value.