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目的 比较模拟失重对不同发育阶段大鼠骨代谢和负重骨生物力学性能影响的差异。方法 对不同月龄SD大鼠尾吊4周后,以生化和放免法测动物骨代谢指标;生物材料试验机测负重骨生物力学性能;灰化法和原子吸收分光光度法测骨矿盐和钙量,并进行比较。结果 （1）尾吊4周,大鼠骨形成指标均显著下降（P<0.01）;（2）尾吊鼠血清钙显著增加（P<0.01）;（3）除弹性负荷外（P>0.05）,尾吊使负重骨各力学指标均显著下降（P<0.01）,且最大桡度和最大负荷下降与月龄有关（P<0.05）;（4）尾吊对不同月龄鼠胫骨体积、湿重减少的影响不同（P<0.05）;（5）年幼鼠骨矿盐含量减少4.32％,高于成年鼠的2.78％,但钙丢失为0.53％,远低于成年鼠的3.05％。结论 尾吊模拟失重对不同发育阶段大鼠骨代谢和负重骨生物力学性能变化的影响程度不同。
Objective To compare the effects of simulated weightlessness on the biomechanical properties of bone metabolism and weight-bearing bone in different developmental stages. Methods After 4 weeks of tail-tailed SD rats of different ages, the biochemical and radioimmunoassay methods were used to measure the bone metabolism index. The biomaterial testing machine was used to measure the biomechanical properties of the loaded bone. Ascites and atomic absorption spectrophotometry Calcium amount, and compare. Results (2) The serum calcium in the tail hamster was significantly increased (P <0.01). (3) In addition to the elastic load, the bone formation index (P> 0.05) (P <0.01), and the maximum radial and maximum load declines with age (P <0.05). (4) The tail suspension has no effect on the tibia volume, (5) The content of bone mineral salt in young mice decreased by 4.32%, which was 2.78% higher than that in adult mice, but the calcium loss was 0.53%, much lower than 3.05% of adult mice. Conclusion The effect of simulated tail-suspension weightlessness on the changes of biomechanical properties of bone metabolism and weight-bearing bone in different developmental stages is different.