粘膜组织表面经常与各种微生物接触,特别是呼吸道粘膜每时每刻都暴露在外界环境下,不断受到过敏原、微生物、有毒物质等的刺激。但是,在通常情况下,人们保持着健康稳定的状态。这有赖于粘膜局部免疫防御机制的存在。1963年Tomasi等人首先发现免疫球蛋白A(IgA)是粘膜局部分泌液中的主要抗体成分。由于其分子结构、合成分泌过程、免疫化学性质、生物学功能及抗感染作用机理等方面,均有别于血清IgA,故命名为分泌型IgA(Secretory IgA、SIgA)。20余年来,对SIgA的研究受到免疫学家们的重视,到目前为止,有关SIgA的临床资料和实验室 Mucosal surface often contact with various microorganisms, especially the respiratory mucosa exposed to the external environment at all times and again, continue to be allergens, microorganisms, toxic substances and other stimuli. However, under normal circumstances, people maintain a healthy and stable state. This depends on the mucosal local immune defense mechanism exists. In 1963 Tomasi et al first found that immunoglobulin A (IgA) is the main antibody component in mucosal secretions. Because of its molecular structure, the process of synthesis and secretion, immunochemical properties, biological function and anti-infection mechanism, are different from the serum IgA, so named secretory IgA (Secretory IgA, SIgA). More than 20 years, the study of SIgA by immunologists attention, so far, the clinical data and laboratory SIgA