【摘 要】
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Arsenic trioxide (ATO),a component of the traditional Chinese medicine arsenic sublimate,promotes apoptosis and induces leukemic cell differentiation.Combined w
【机 构】
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Myeloma and Lymphoma Center, Department of Hematology, Changzheng Hospital, Shanghai 200003, China
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Arsenic trioxide (ATO),a component of the traditional Chinese medicine arsenic sublimate,promotes apoptosis and induces leukemic cell differentiation.Combined with all-trans-retinotic acid (ATRA),ATO has become the first-line induction therapy in treating acute promyelocytic leukemia (APL).The most common side effects of ATO include hepatotoxicity,gastrointestinal symptoms,water-sodium retention,and nervous system damage.In this report,we present a rare side effect,rhabdomyolysis,in a 68-year-old female APL patient who was treated with ATO.After taking 10 mg ATO daily for 6 days,she presented shortness of breath,myodynia,elevated creatine kinase,and acute renal insufficiency.This report describes the first case of ATO-induced rhabdomyolysis.
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