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乳腺癌转移抑制基因(BRMS1)有抑制肿瘤细胞转移的能力,可减少转移的发生,其作用机制复杂多样而又非典型,它可与mSin3-HDAC复合体相互作用,恢复间隙连接介导的细胞间连接通讯,抑制磷酸肌醇信号转导等。全文综述BRMS1作用机制的研究进展。
Breast cancer metastasis suppressor gene (BRMS1) has the ability to inhibit the metastasis of tumor cells and reduces the metastasis. Its mechanism of action is complex and atypical. It interacts with the mSin3-HDAC complex and restores the gap junction-mediated cells Between the communication, inhibition of phosphoinositide signal transduction. The paper reviews the research progress of BRMS1 mechanism.