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目的:探讨原发性高血压患者颈-股动脉脉搏波传导速度(cfPWV)与血浆脑钠肽(BNP)水平的关系。方法:95例符合入选标准的无左室肥厚的原发性高血压患者,用动脉硬化测定仪测量其cfPWV,并依据cfPWV值分成3组,采用荧光免疫法定量测定其血清BNP水平。结果:各组患者在年龄、TC、空腹血糖、LDL、HDL、血肌酐、血尿素氮等生化指标和体质指数等方面比较均差异无统计学意义(均P>0.05),血压之间差异有统计学意义(P<0.01)。3组患者血清BNP水平随cfPWV增加而增加(P<0.01),BNP水平与cfPWV呈正相关(r=0.694,P=0.026);二尖瓣舒张早期充盈速度与舒张晚期充盈速度比值(E/A)随cfPWV、BNP水平的增加而降低(P<0.01),E/A值与cfPWV呈负相关(r=-0.837,P=0.041)。结论:在尚未出现左室肥厚的原发性高血压患者中,BNP可作为患者动脉硬化水平的预测指标。
Objective: To investigate the relationship between carotid-femoral pulse wave velocity (cfPWV) and plasma brain natriuretic peptide (BNP) levels in patients with essential hypertension. Methods: Ninety-five patients with essential hypertension without left ventricular hypertrophy were enrolled in the study. The cfPWV was measured by arteriosclerosis analyzer and divided into three groups according to the cfPWV value. The serum BNP level was quantitatively determined by fluorescence immunoassay. Results: There was no significant difference in biochemical indexes such as age, TC, fasting blood glucose, LDL, HDL, serum creatinine, blood urea nitrogen and body mass index among all groups (all P> 0.05) Statistical significance (P <0.01). Serum BNP level increased with the increase of cfPWV in 3 groups (P <0.01), BNP level was positively correlated with cfPWV (r = 0.694, P = 0.026); the ratio of early diastolic filling velocity to late diastolic filling velocity (E / A ) Decreased with the increase of cfPWV and BNP (P <0.01). The E / A value was negatively correlated with cfPWV (r = -0.837, P = 0.041). Conclusion: BNP can be used as a predictor of arteriosclerosis in patients with essential hypertension without left ventricular hypertrophy.