Fractalkine(Fkn)是趋化因子CX3C亚家族中目前发现的唯一成员,cx3cr1是其特异性受体.Fkn/cx3 cr1参与炎症、肿瘤、自身免疫疾病、变态反应、获得性免疫缺陷综合征等多种疾病,同时多种病理生理作用是通过小胶质细胞来完成的.本文就Fkn/cx3 cr1与小胶质细胞在年龄相关性黄斑病变、急性光损伤疾病、视网膜新生血管性疾病、糖尿病视网膜疾病、葡萄膜炎等眼底疾病中的研究进展进行综述.“,”Fractalkine (Fkn) is the only member of CX3C subfamily of chemokine currently found,cx3cr1 is its specific receptor.Fkn/cx3cr1 is involved in inflammation,cancer,autoimmune diseases,allergy,acquired immune deficiency syndrome and other diseases,while its variety of pathophysiological role is accomplished by microglia.Functions of Fkn/cx3cr1 and microglia in age-related macular degeneration,acute light damage disease,retinal vascular disease,diabetic retinopathy disease,uveitis and other retina disease were reviewed in this article.