论文部分内容阅读
测定了298K时2-芳基丙酸类药物普拉洛芬、酮洛芬、卡洛芬、萘普生在二元混合溶剂中的荧光光谱,采用Jouyban-Acree模型拟合了荧光强度(FI)数据,平均偏差为1.9%,当采用Yalkowsky方程拟合时,平均偏差达到13.5%。首次采用Jouyban-Acree模型拟合最大荧光发射波长,平均误差为0.3nm,而采用Y alkow sky方程时,误差为0.9nm。结果表明Jouy ban-A cree模型能够很好预测混合水溶液中药物的荧光强度及荧光最大发射波长,当数据较少时,Y alkow sky方程也能预测混合溶剂中的最大发射波长。
Fluorescence spectra of 2-arylpropionic acid drugs, such as pranoprofen, ketoprofen, carprofen and naproxen, were measured at 298K. The fluorescence intensity was fitted by Jouyban-Acree model ) Data, with an average deviation of 1.9%. When using the Yalkowsky equation, the average deviation was 13.5%. For the first time, the Jouyban-Acree model was used to fit the maximum fluorescence emission wavelength with an average error of 0.3 nm. However, with the Y alkow sky equation, the error was 0.9 nm. The results show that the Jouy ban-A cree model can well predict the fluorescence intensity and the maximum fluorescence emission wavelength in the mixed aqueous solution. When the data is small, the Y alkow sky equation can also predict the maximum emission wavelength in the mixed solvent.