目的 观察右美托咪定对膀胱肿瘤电切患者导尿管所致不适的预防效果.方法 将78 例ASA Ⅰ-Ⅱ级择期全麻下行经尿道膀胱肿瘤电切术的患者随机分为两组:生理盐水组(C组,n＝39),右美托咪定组(D组,n＝39).两组患者均行常规全麻诱导,手术开始时,D组予以右美托咪定0.5 μg/kg,10 min内静脉泵注,C组予以等量生理盐水泵注.记录两组患者泵注前、泵注后的收缩压、舒张压、心率、手术时间以及拔管时间,并记录术后1 h及术后6 h患者导尿管所致不适严重程度、发生率以及患者镇静程度.结果 与C组相比,D组患者术后1 h及6 h导尿管相关不适严重程度明显减轻,且发生率显著降低(33.3% vs 56.4%,56.4% vs 79.5%,P均＜0.05);D组患者在术后1 h镇静程度偏深,术后6 h两组间镇静程度差异无统计学意义.结论 右美托咪定可以显著减轻膀胱肿瘤电切患者术后导尿管相关不适的严重程度并降低其发生率,同时不显著增加其他副作用.“,”Objective To observe the prevention effect of intraoperative dexmedetomidine administration on postoperative catheter-related bladder discomfort (CRBD) in patients undergoing transurethral bladder tumor resection. Methods 78 ASA Ⅰ-Ⅱ patients undergoing transurethral bladder tumor resection were randomly divided into two groups: saline group (group C, n＝39) and dexmedetomidine group (group D, n＝39). Both groups were induced by routine general anesthesia. At the beginning of the operation, group D was given dexmedetomidine 0.5 μg/kg, intravenously in 10 minutes, and group C was given the same amount of saline pumping. The systolic pressure, diastolic pressure and heart rate were recorded before and after pumping in both groups. The time of operation and extubation were also recorded. The incidence and severity of CRBD and sedation level were assessed 1 h and 6 h after extubation. Results At 1 h and 6 h after extubation, the incidence and severity of CRBD in group D were significantly reduced compared with that of group C (33.3% vs 56.4%, 56.4% vs 79.5%, all P＜0.05). At 1 h, dexmedetomidine induce deeper sedation in group D, while at 6 h, there was no difference between the two groups. Conclusion The injection of dexmedetomidine (0.5 μg/kg) intraoperatively reduced the incidence and severity of CRBD and without causing significant side effects.