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目的:评价经阴道植入轻型钛化聚丙烯网片TiLOOP的盆底重建术的临床短期疗效和安全性。方法:回顾性分析南京医科大学附属无锡妇幼保健院2017年11月至2019年7月，以阴道前壁膨出Ⅲ~Ⅳ度为主的50例盆腔器官脱垂（POP）患者，对其实施经阴道植入TiLOOP网片的盆底重建术，其中自行裁剪TiLOOP网片的“协和式”盆底重建术37例、TiLOOP Total 6套盒网片的盆底重建术13例。评价术后各项主观指标［包括患者整体印象改善评分（PGI-I）、盆底不适调查表简表（PFDI-20）、盆底功能影响问卷简表（PFIQ-7）、盆腔器官脱垂与尿失禁性生活问卷（PISQ-12）］、客观指标（包括临床疗效评定为“成功”）以及并发症的发生情况。结果:50例POP患者的随访时间为（18±6）个月。手术成功率为90%（45/50），单独阴道前壁、顶端、后壁脱垂的复发率分别为2%（1/50）、2%（1/50）、6%（3/50）；无一例行再次手术或子宫托治疗。PGI-I显示，50例患者均主观满意，其中明显改善者46例（92%，46/50）、有改善者4例（8%，4/50）；术后3、6、12个月随访，PFDI-20及PFIQ-7评分均较术前显著下降，差异均有统计学意义（n P均0.05），无新发性交痛。网片暴露率为12%（6/50），新发压力性尿失禁的发生率为4%（2/47）。n 结论:经阴道植入TiLOOP网片的盆底重建术是一种安全、有效的手术方式，短期疗效较好，但如何减少网片暴露仍需继续探究。“,”Objective:To evaluate the short-term clinical efficacy and safety of transvaginal pelvic floor reconstruction with TiLOOP mesh, a titanized polypropylene lightweight mesh.Methods:From November 2017 to July 2019, 50 patients underwent surgery, who were with anterior vaginal prolapse stage Ⅲ-Ⅳ and (or) apical prolapse and posterior vaginal prolapse (stage Ⅰ-Ⅱ); 37 patients underwent self-cut TiLOOP mesh and 13 patients underwent pre-cut mesh-kit procedure. The subjective and objective parameters (including surgical success) of them were evaluated.Results:The mean follow-up time was (18±6) months. The overall surgical success rate was 90% (45/50). Prolapse recurrence rates were isolated anterior 2% (1/50), isolated apical 2% (1/50) and isolated posterior 6% (3/50). None of recurrent patients underwent re-treatment, including either surgery or use of a pessary at last follow-up. According to patient global impression of improvement (PGI-I), 46 patients (92%, 46/50) were very much better, and 4 patients (8%, 4/50) were much better. After the operation, pelvic floor distress inventory-short form 20 (PFDI-20) and pelvic floor impact questionnaire-short form 7 (PFIQ-7) scores were significantly lower than those before operation (all n P0.05), but without dyspareunia. The vaginal mesh erosion rate was 12% (6/50) and the stress urinary incontinence was observed in 2 cases (4%, 2/47).n Conclusion:Transvaginal pelvic floor reconstruction with TiLOOP mesh is a safe and effective surgery, short-term efficacy is acceptable, how to reduce the mesh erosion still need to be explored.