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合成新鱼腥草素(N eo-Honttuyninum),十二酰乙醛亚硫酸钠为我院药学系所合成,并认为对附件炎,宫颈炎,盆腔炎与呼吸道感染等炎症疾患有肯定疗效,现已广泛用于临床抗炎治疗,无明显副作用。为探索本药对肿瘤的作用,我室曾研究合成新鱼腥草素对小鼠移植型肝癌的作用,体外实验发现,其对~3H-胸腺嘧啶核苷及~3H-尿嘧啶核苷的平均抑制率分别为98.25 ±0.68及94.58±2.77,表明新鱼腥草素能抑制小鼠肝癌腹水细胞的DNA及RNA的合成。为进一步探讨本药作用特点,我们观察了本药对小鼠肝癌腹水细胞周期的影响。
Synthesized Neo-Hottuynynum, sodium dodecanoylsodium sulfite, synthesized by the Department of Pharmacy of our hospital, and considered that it has a positive effect on inflammatory diseases such as attachment inflammation, cervicitis, pelvic inflammatory disease and respiratory tract infection. Widely used in clinical anti-inflammatory treatment, no obvious side effects. In order to explore the effect of this drug on tumors, our laboratory studied the effects of new Houttuyfonate on transplanted liver cancer in mice. In vitro experiments found that it is effective for ~3H-thymidine and ~3H-uridine. The average inhibition rates were 98.25 ± 0.68 and 94.58 ± 2.77, respectively, indicating that Houttuyfonate could inhibit the synthesis of DNA and RNA in mouse ascites cells. To further explore the characteristics of the drug, we observed the effect of the drug on the cell cycle of mouse ascites.