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目的调查扬州市江都区135例急性乙型肝炎病毒(Hepatitis B virus,HBV)感染孕妇的临床特征及生活质量。方法选取2013年9月-2016年9月扬州市江都区确诊的600例女性急性HBV感染者作为研究对象。其中135例急性HBV感染孕妇作为研究组,465例非妊娠期急性HBV感染者作为对照组。于入院接受治疗时采集所有患者一般临床资料,详细询问患者入院症状、体征,并调查患者生活质量。患者入院时接受肝细胞合成代谢指标检测[血清谷丙转氨酶(ALT)、白蛋白(ALB)、总胆红素(TBIL)、转肽酶(GGT)]等,同时检测乙肝病毒血清学指标[e抗原(HBe Ag)、乙肝表面抗原(HBs Ag)]。结果研究组黄疸发生率高于对照组,纳差、发热发生率均低于对照组,差异有统计学意义(P<0.05);两组腹水、乏力、肝性脑病发生率比较,差异无统计学意义(P>0.05);研究组活力、总体健康评分均低于对照组,差异有统计学意义(P<0.05);两组生理功能、生理职能、社会功能、情感职能、精神状态、疼痛评分比较,差异无统计学意义(P>0.05);研究组血清ALT、ALB、GGT水平及HBe Ag阳性率、HBe Ag血清学转换率均低于对照组,TBIL水平高于对照组,差异有统计学意义(P<0.05);两组HBs Ag阳性率、HBs Ag血清学转换率比较,差异无统计学意义(P>0.05)。结论扬州市江都区急性HBV感染孕妇临床特征主要表现为纳差、乏力、黄疸等症状,生活质量较差。
Objective To investigate the clinical characteristics and quality of life of 135 pregnant women infected with Hepatitis B virus (HBV) in Jiangdu District, Yangzhou City. Methods From September 2013 to September 2016, 600 women with acute HBV infection diagnosed in Jiangdu District of Yangzhou City were selected as the research object. 135 pregnant women with acute HBV infection as study group and 465 non-pregnant women with acute HBV infection as control group. At the time of admission, the general clinical data of all patients were collected, and the symptoms and signs of patients were asked in detail and the quality of life of the patients was investigated. The patients were admitted to hospital for detection of hepatocyte metabolic index (ALT, ALB, total bilirubin (TBIL), transpeptidase (GGT)], etc. Meanwhile, the serological indicators of hepatitis B were detected [ e antigen (HBeAg), hepatitis B surface antigen (HBsAg)]. Results The incidence of jaundice in the study group was higher than that in the control group, and the incidence of anorexia and fever was lower than that of the control group (P <0.05). The incidence of ascites, fatigue and hepatic encephalopathy were not statistically different between the two groups (P> 0.05). The vitality and overall health scores of the study group were lower than those of the control group (P <0.05). The physiological function, physiological function, social function, emotional function, mental status, pain (P> 0.05). Serum levels of ALT, ALB, GGT, HBe Ag positive rate and HBeAg seroconversion rate were lower in the study group than in the control group, TBIL level was higher than the control group, the difference was (P <0.05). There was no significant difference in HBsAg positive rate and HBsAg seroconversion rate between the two groups (P> 0.05). Conclusions The clinical features of pregnant women with acute HBV infection in Jiangdu District of Yangzhou City are mainly characterized by anorexia, fatigue and jaundice, with poor quality of life.